Article

Heterogenous impairment of α-cell function in type 2 diabetes is linked to cell maturation state

2021-04-08

Abstract excerpt

In diabetes, glucagon secretion from pancreatic α-cells is dysregulated. We examined α-cells from human donors and mice using combined electrophysiological, transcriptomic, and computational approaches. Rising glucose suppresses α-cell exocytosis by reducing P/Q-type Ca 2+ channel activity, and this is disrupted in type 2 diabetes (T2D). Upon high-fat-feeding of mice, α-cells shift towards a ‘β-cell-like’ electro...

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Literature Corpus work: fe81519e-ac9a-5a3f-a36f-2c1ee42e211b
DOI: 10.1101/2021.04.08.435504

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