Article

Glucagon and GLP-1 Accelerate Pseudo-Islet Assembly and Unmask Sex-Specific Islet Fragmentation Dynamics

2025-08-12

Abstract excerpt

Pancreatic hormones are best known for their role in regulating blood sugar levels as well as islet cell function and proliferation. However, their impact on maintaining and inducing cell aggregation in culture remains under-explored. In this study, we investigated the effects of glucagon (GCG) and glucagon-like-peptide 1(GLP-1) on the formation and integrity of human islet clusters. Native human islets were disso...

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Literature Corpus work: 6c28b417-6979-5c0e-ac56-a41819dfc3d2
DOI: 10.1101/2025.08.10.669547

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