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Labeling and Characterization of Human GLP-1-Secreting L-cells in Primary Ileal Organoid Culture

1 Jun 2020

Abstract excerpt

Glucagon-like peptide-1 (GLP-1) from intestinal L-cells stimulates insulin secretion and reduces appetite after food ingestion, and it is the basis for drugs against type-2 diabetes and obesity. Drugs targeting L- and other enteroendocrine cells are under development, with the aim to mimic endocrine effects of gastric bypass surgery, but they are difficult to develop without human L-cell models. Human ileal...

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PMID: 32610134
DOI: 10.1016/j.celrep.2020.107833

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