Article

Diseased human pancreas and liver microphysiological system for preclinical diabetes research

2023-07-03

Abstract excerpt

<h4>ABSTRACT</h4> Current research on metabolic disorders such as type 2 diabetes relies on animal models because multi-organ diseases cannot be well studied with the standard in vitro assays. Here, we connect models of key metabolism organs, pancreas and liver, on a microfluidic chip to enable diabetes research in a human-based preclinical system. Aided by mechanistic mathematical modelling, we developed a two-...

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Literature Corpus work: b41d08b0-2de8-5e81-8fca-4b45373895cf
DOI: 10.1101/2023.07.03.547412

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