Article

Direct interrogation of context-dependent GPCR activity with a universal biosensor platform

2024-01-02

Abstract excerpt

<h4>ABSTRACT</h4> G protein-coupled receptors (GPCRs) are the largest family of druggable proteins in the human genome, but progress in understanding and targeting them is hindered by the lack of tools to reliably measure their nuanced behavior in physiologically-relevant contexts. Here, we developed a collection of compact ONE vector G -protein O ptical (ONE-GO) biosensor constructs as a scalable platform tha...

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Literature Corpus work: 2e6da89a-2484-545a-bfab-2a4e5b3159f2
DOI: 10.1101/2024.01.02.573921

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