Article

A multilayered post-GWAS analysis pipeline defines functional variants and target genes for systemic lupus erythematosus (SLE)

2023-04-07

Abstract excerpt

<h4>Objectives</h4> Systemic lupus erythematosus (SLE), an autoimmune disease with incompletely understood etiology, has a strong genetic component. Although genome-wide association studies (GWAS) have revealed multiple SLE susceptibility loci and associated single nucleotide polymorphisms (SNPs), the precise causal variants, target genes, cell types, tissues, and mechanisms of action remain largely unknown. <h4>M...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c35e1f79-1148-503c-a366-0d6582d189bf
DOI: 10.1101/2023.04.07.23288295

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A multilayered post-GWAS analysis pipeline defines functional variants and target genes for systemic lupus erythematosus (SLE)DOI 10.1101/2023.04.07.23288295Read

A Multilayered Post-Genome-Wide Association Study Analysis Pipeline Defines Functional Variants and Target Genes for Systemic Lupus Erythematosus.Semantic proximity Read

Single-cell CRISPR activation screens in primary B cells discover gene regulatory mechanisms for hundreds of autoimmune risk lociSemantic proximity Read

High-throughput identification of functional regulatory SNPs in systemic lupus erythematosusSemantic proximity Read

High-throughput identification of functional regulatory SNPs in systemic lupus erythematosus.Semantic proximity Read

A review of genetic risk in systemic lupus erythematosus.Semantic proximity Read

Human follicular helper T cell promoter connectomes reveal novel genes and regulatory elements at SLE GWAS lociSemantic proximity Read

CRISPRa screen on a genetic risk locus shared by multiple autoimmune diseases identifies a dysfunctional enhancer that affects <i>IRF8</i> expression through cooperative lncRNA and DNA methylation machinerySemantic proximity Read

Genetic advances in systemic lupus erythematosus: an update.Semantic proximity Read

Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus.Semantic proximity Read

KLF2 enhancer variant rs4808485 increases lupus risk by modulating inflammasome machinery and cellular homoeostasis.Semantic proximity Read

Confirmation of five novel susceptibility loci for systemic lupus erythematosus (SLE) and integrated network analysis of 82 SLE susceptibility loci.Semantic proximity Read

Recent advances in understanding the genetic basis of systemic lupus erythematosus.Semantic proximity Read