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Article

A Multilayered Post-Genome-Wide Association Study Analysis Pipeline Defines Functional Variants and Target Genes for Systemic Lupus Erythematosus.

Arthritis & rheumatology (Hoboken, N.J.) - 1 Jul 2024

Fazel-Najafabadi Mehdi, Looger Loren L, Rallabandi Harikrishna Reddy, Nath Swapan K

Abstract excerpt

OBJECTIVE: Systemic lupus erythematosus (SLE), an autoimmune disease with incompletely understood etiology, has a strong genetic component. Although genome-wide association studies (GWASs) have revealed multiple SLE susceptibility loci and associated single-nucleotide polymorphisms (SNPs), the precise causal variants, target genes, cell types, tissues, and mechanisms of action remain largely unknown. METHODS:...

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PMID: 38369936
DOI: 10.1002/art.42829
PMCID: PMC11213670

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