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Article

High-density genotyping of immune-related loci identifies new SLE risk variants in individuals with Asian ancestry.

Nature genetics - 1 Mar 2016

Sun Celi, Molineros Julio E, Looger Loren L, Zhou Xu-Jie, Kim Kwangwoo, Okada Yukinori, Ma Jianyang, Qi Yuan-Yuan, Kim-Howard Xana, Motghare Prasenjeet, Bhattarai Krishna, Adler Adam, Bang So-Young, Lee Hye-Soon, Kim Tae-Hwan, Kang Young Mo, Suh Chang-Hee, Chung Won Tae, Park Yong-Beom, Choe Jung-Yoon, Shim Seung Cheol, Kochi Yuta, Suzuki Akari, Kubo Michiaki, Sumida Takayuki, Yamamoto Kazuhiko, Lee Shin-Seok, Kim Young Jin, Han Bok-Ghee, Dozmorov Mikhail, Kaufman Kenneth M, Wren Jonathan D, Harley John B, Shen Nan, Chua Kek Heng, Zhang Hong, Bae Sang-Cheol, Nath Swapan K

Abstract excerpt

Systemic lupus erythematosus (SLE) has a strong but incompletely understood genetic architecture. We conducted an association study with replication in 4,478 SLE cases and 12,656 controls from six East Asian cohorts to identify new SLE susceptibility loci and better localize known loci. We identified ten new loci and confirmed 20 known loci with genome-wide significance. Among the new loci, the most significant...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26808113
DOI: 10.1038/ng.3496
PMCID: PMC4767573

Genes

DEF6
RASGRP1
SIGLEC6
SYNGR1
TCF7
TERT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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