Article

Variant-to-function mapping in lupus links <i>IL12A</i> to the expansion of disease-associated B cells with a cytotoxic program

2026-07-29

Abstract excerpt

<h4>ABSTRACT</h4> Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by over 200 risk variants identified through genome-wide association studies. While the majority of these are non-coding variants with unresolved functions, elucidating their mechanisms is critical for prioritizing therapeutic targets with increased clinical success. Several SLE risk loci span genes involved in the...

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Literature Corpus work: 7a1eb93f-9c63-5b91-acbe-675a791cd66d
DOI: 10.64898/2026.07.28.26359131

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