Article

Dynamical modeling of the H3K27 epigenetic landscape in mouse embryonic stem cells

2021-10-01

Abstract excerpt

The Polycomb system via the methylation of the lysine 27 of histone H3 (H3K27) plays central roles in the silencing of many lineage-specific genes during development. Recent experimental evidence suggested that the recruitment of histone modifying enzymes like the Polycomb repressive complex 2 (PRC2) at specific sites and their spreading capacities from these sites are key to the establishment and maintenance of a...

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Literature Corpus work: 7193af70-0516-5ab0-bcd7-149054360698
DOI: 10.1101/2021.09.30.462529

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