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Role of transcription complexes in the formation of the basal methylation pattern in early development

26 Sept 2018

Abstract excerpt

Following erasure in the blastocyst, the entire genome undergoes de novo methylation at the time of implantation, with CpG islands being protected from this process. This bimodal pattern is then preserved throughout development and the lifetime of the organism. Using mouse embryonic stem cells as a model system, we demonstrate that the binding of an RNA polymerase complex on DNA before de novo methylation is...

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PMID: 30257947
DOI: 10.1073/pnas.1804755115

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