Article
A model for transmission of the H3K27me3 epigenetic mark.
Nature cell biology - 1 Nov 2008
Hansen Klaus H, Bracken Adrian P, Pasini Diego, Dietrich Nikolaj, Gehani Simmi S, Monrad Astrid, Rappsilber Juri, Lerdrup Mads, Helin Kristian
Abstract excerpt
Organization of chromatin by epigenetic mechanisms is essential for establishing and maintaining cellular identity in developing and adult organisms. A key question that remains unresolved about this process is how epigenetic marks are transmitted to the next cell generation during cell division. Here we provide a model to explain how trimethylated Lys 27 of histone 3 (H3K27me3), which is catalysed by the...
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