Article

Forecasting histone methylation by Polycomb complexes with minute-scale precision

2023-06-17

Abstract excerpt

All animals use the Polycomb system to epigenetically repress developmental genes. The repression requires tri-methylation of Lysine 27 of histone H3 (H3K27me3) by Polycomb Repressive Complex 2 (PRC2), but the dynamics of this process is poorly understood. To bridge the gap, we developed a computational model that forecasts H3K27 methylation in Drosophila with high temporal resolution and spatial accuracy of cont...

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Literature Corpus work: 6ab52d14-f0a2-523d-9006-c41aa1f07b51
DOI: 10.1101/2023.06.16.545270

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