Article

Histone H3K27 methylation states are sequentially catalyzed in cycling cells

2026-05-04

Abstract excerpt

Polycomb domains form at silenced genes and are marked by histone H3 lysine 27 tri-methylation, but it is unclear how this methylation is maintained following DNA replication in proliferating cells. Here, we use CUT&Tag chromatin profiling to track the dynamics of H3K27 methylation in human cells. We find that tri-methylation in Polycomb domains is maintained by stepwise methylation after DNA replication. Outside...

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Literature Corpus work: 17aff5fb-5d42-576f-8efc-6e09b817a3e0
DOI: 10.64898/2026.04.30.721988

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