Article

Spatio-temporal T cell tracking for personalized TCR-T designs in childhood cancer

2024-11-19

Abstract excerpt

Immune checkpoint inhibition (ICI) has revolutionized oncology, offering extended survival and long-term remission in previously incurable cancers. While highly effective in tumors with high mutational burden, lowly mutated cancers, including pediatric malignancies, present low response rate and limited predictive biomarkers. Here, we present a framework for the identification and validation of tumor-reactive T ce...

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Literature Corpus work: 7144da8b-7b7f-5f5f-9229-fb2c7ec17394
DOI: 10.1101/2024.11.18.624071

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