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Single-cell analyses identify circulating anti-tumor CD8 T cells and markers for their enrichment

10 Dec 2020

Abstract excerpt

The ability to monitor anti-tumor CD8+ T cell responses in the blood has tremendous therapeutic potential. Here, we used paired single-cell RNA and TCR sequencing to detect and characterize "tumor-matching" (TM) CD8+ T cells in the blood of mice with MC38 tumors or melanoma patients using the TCR as a molecular barcode. TM cells showed increased activation compared with nonmatching T cells in blood and were less...

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PMID: 33651880
DOI: 10.1084/jem.20200920

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