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Article

T-cell repertoire diversity: friend or foe for protective antitumor response?

22 Dec 2022

Abstract excerpt

Profiling the T-Cell Receptor (TCR) repertoire is establishing as a potent approach to investigate autologous and treatment-induced antitumor immune response. Technical and computational breakthroughs, including high throughput next-generation sequencing (NGS) approaches and spatial transcriptomics, are providing unprecedented insight into the mechanisms underlying antitumor immunity. A precise spatiotemporal...

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PMID: 36550555
DOI: 10.1186/s13046-022-02566-0

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