Article

Single-cell, Spatially-Resolved TCR Profiling Links T Cell Phenotype and Clonality in Human Tumors

2025-08-08

Abstract excerpt

<h4>Summary</h4> Despite remarkable success in melanoma and other cancers, immune checkpoint blockade has shown limited efficacy in head and neck squamous cell carcinoma (HNSCC), with durable responses in only ∼10% of patients. This is paradoxical given the abundant infiltration of CD8⁺ T cells in HNSCC, suggesting that current T cell profiling methods fail to fully capture functional anti-tumor immunity and that...

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Literature Corpus work: d4da7c59-2135-5e2b-9a2f-666600f71bce
DOI: 10.1101/2025.08.06.668925

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