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Article

Immuno-transcriptomic profiling of extracranial pediatric solid malignancies

1 Nov 2021

Abstract excerpt

We perform an immunogenomics analysis utilizing whole-transcriptome sequencing of 657 pediatric extracranial solid cancer samples representing 14 diagnoses, and additionally utilize transcriptomes of 131 pediatric cancer cell lines and 147 normal tissue samples for comparison. We describe patterns of infiltrating immune cells, T cell receptor (TCR) clonal expansion, and translationally relevant immune...

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PMID: 34818552
DOI: 10.1016/j.celrep.2021.110047

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