Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The T cell receptor landscape of childhood brain tumors

19 Mar 2025

Abstract excerpt

The diverse T cell receptor (TCR) repertoire confers the ability to recognize an almost unlimited array of antigens. Characterization of antigen specificity of tumor-infiltrating lymphocytes (TILs) is key for understanding antitumor immunity and for guiding the development of effective immunotherapies. Here, we report a large-scale comprehensive examination of the TCR landscape of TILs across the spectrum of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Immunotherapy and Biomarkers
Share to CAR-T cell therapy research
Share to Glioma Diagnosis and Treatment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40106578
DOI: 10.1126/scitranslmed.adp0675

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The T cell receptor landscape of childhood brain tumorsPMID 40106578Read ↗

Transcriptional immunogenomic analysis reveals distinct immunological clusters in paediatric nervous system tumoursSemantic proximity Read ↗

A novel transcriptional signature identifies T-cell infiltration in high-risk paediatric cancer.Semantic proximity Read ↗

Dissecting the immune landscape in pediatric high-grade glioma reveals cell state changes under therapeutic pressureSemantic proximity Read ↗

Immuno-transcriptomic profiling of extracranial pediatric solid malignanciesSemantic proximity Read ↗

Spatially resolved T cell receptor tracking reveals γδT cell localization to tumor-rich regions in high-risk neuroblastoma: A Report from the Children’s Oncology GroupSemantic proximity Read ↗

Spatio-temporal T cell tracking for personalized TCR-T designs in childhood cancerSemantic proximity Read ↗

The landscape of antigen-specific T cells in human cancersSemantic proximity Read ↗

Investigation of Antigen-Specific T-Cell Receptor Clusters in Human CancersSemantic proximity Read ↗

Immunophenotyping of pediatric brain tumors: correlating immune infiltrate with histology, mutational load, and survival and assessing clonal T cell response.Semantic proximity Read ↗

Genomic and Transcriptomic Analysis of Relapsed and Refractory Childhood Solid Tumors Reveals a Diverse Molecular Landscape and Mechanisms of Immune Evasion.Semantic proximity Read ↗

T-cell repertoire diversity: friend or foe for protective antitumor response?Semantic proximity Read ↗

The Growing Relevance of Immunoregulation in Pediatric Brain TumorsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.