Article

Single-cell meta-analysis of T cells reveals clonal dynamics of response to checkpoint immunotherapy

2024-09-27

Abstract excerpt

<h4>Summary</h4> Despite the crucial role of T cell clones in the anti-tumor activity, their characterization and association with clinical outcome following immune checkpoint inhibitors (ICI) is lacking. Here we analyzed paired single-cell RNA-sequencing/T-cell receptor sequencing of 767,606 T cells from 460 samples spanning 6 cancer types. We found a robust signature of response based on expanded CD8 + clones...

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Literature Corpus work: e6ee13c9-0a9a-507f-9774-bec467545257
DOI: 10.1101/2024.09.25.614877

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