Article

Membrane remodeling properties of the Parkinson’s disease protein LRRK2

2022-08-10

Abstract excerpt

Mutations in Leucine-rich repeat kinase 2 (LRRK2) are responsible for late-onset autosomal dominant Parkinson’s disease (PD). LRRK2 has been implicated in a wide range of physiological processes including membrane repair in the endolysosomal system. Here, using cell free systems, we report that purified LRRK2 directly binds acidic lipid bilayers with a preference for highly curved bilayers. While this binding is n...

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Literature Corpus work: 710f8a36-a413-5a2b-b272-4ebd01115e45
DOI: 10.1101/2022.08.10.503505

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