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Article

Structural Biology of LRRK2 and its Interaction with Microtubules.

Movement disorders : official journal of the Movement Disorder Society - 1 Nov 2021

Leschziner Andres E, Reck-Peterson Samara L

Abstract excerpt

Mutations in leucine rich repeat kinase 2 (LRRK2) are a major cause of familial Parkinson's disease (PD) and a risk factor for its sporadic form. LRRK2 hyperactivity has also been reported in sporadic PD, making LRRK2 an appealing target for PD small-molecule therapeutics. At a cellular level, increasing evidence suggests that LRRK2 regulates membrane trafficking. Under some conditions LRRK2 also associates with...

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Identifiers

PMID: 34423856
DOI: 10.1002/mds.28755
PMCID: PMC9290818

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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