Article
Membrane remodeling properties of the Parkinson's disease protein LRRK2.
Proceedings of the National Academy of Sciences of the United States of America - 24 Oct 2023
Wang Xinbo, Espadas Javier, Wu Yumei, Cai Shujun, Ge Jinghua, Shao Lin, Roux Aurélien, De Camilli Pietro
Abstract excerpt
Mutations in Leucine-rich repeat kinase 2 (LRRK2) are responsible for late-onset autosomal dominant Parkinson's disease. LRRK2 has been implicated in a wide range of physiological processes including membrane repair in the endolysosomal system. Here, using cell-free systems, we report that purified LRRK2 directly binds acidic lipid bilayers with a preference for highly curved bilayers. While this binding is...
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