Article

Cell-type and dynamic state govern genetic regulation of gene expression in heterogeneous differentiating cultures

2024-05-03

Abstract excerpt

Identifying the molecular effects of human genetic variation across cellular contexts is crucial for understanding the mechanisms underlying disease-associated loci, yet many cell-types and developmental stages remain underexplored. Here we harnessed the potential of heterogeneous differentiating cultures ( HDCs ), an in vitro system in which pluripotent cells asynchronously differentiate into a broad spectrum o...

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Literature Corpus work: 710c7f2e-3b54-59dc-a114-498c2e8968b7
DOI: 10.1101/2024.05.02.592174

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