Article

A robust model for cell type-specific interindividual variation in single-cell RNA sequencing data

2023-02-27

Abstract excerpt

The development of single-cell RNA sequencing (scRNA-seq) offers opportunities to characterize cellular heterogeneity at unprecedented resolution. Although scRNA-seq has been widely used to identify and characterize gene expression variation across cell types and cell states based on their average gene expression profiles, most studies ignore variation across individual donors. Modelling this inter-individual vari...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2d29d237-7322-56b0-8072-8e6d649bb15c
DOI: 10.1101/2023.02.24.529987

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A robust model for cell type-specific interindividual variation in single-cell RNA sequencing dataDOI 10.1101/2023.02.24.529987Read

Single-cell allele-specific expression analysis reveals dynamic and cell-type-specific regulatory effectsSemantic proximity Read

Single-cell allele-specific expression analysis reveals dynamic and cell-type-specific regulatory effects.Semantic proximity Read

Single-Cell Sequencing Reveals Lineage-Specific Dynamic Genetic Regulation of Gene Expression During Human Cardiomyocyte DifferentiationSemantic proximity Read

Extent, heritability, and functional relevance of single cell expression variability in highly homogeneous populations of human cellsSemantic proximity Read

Single-cell RNA-sequencing of differentiating iPS cells reveals dynamic genetic effects on gene expressionSemantic proximity Read

Identifying systematic variation at the single-cell level by leveraging low-resolution population-level dataSemantic proximity Read

Cell-type and dynamic state govern genetic regulation of gene expression in heterogeneous differentiating culturesSemantic proximity Read

CellRegMap: A statistical framework for mapping context-specific regulatory variants using scRNA-seqSemantic proximity Read

Single-cell mapper (scMappR): using scRNA-seq to infer cell-type specificities of differentially expressed genesSemantic proximity Read

Single-cell splicing analysis with <i>ISSAC</i> links cell type-specific and cell state-dependent sQTLs to neurological disordersSemantic proximity Read

Recommendations of Scrna-Seq Differential Gene Expression Analysis Based on Comprehensive BenchmarkingSemantic proximity Read

Discovery and characterization of variance QTLs in human induced pluripotent stem cellsSemantic proximity Read