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DRCTdb: disease-related cell type analysis to decode cell type effect and underlying regulatory mechanisms.

Communications biology - 28 Sept 2024

Kong Yunhui, Jiang Junyao, Kong Weikang, Qin Sheng

Abstract excerpt

Understanding the molecular mechanisms underlying genetic diseases is challenging due to environmental and genetic factors. Genome-wide association studies (GWAS) have identified numerous genetic loci, but their functional implications are largely unknown. Single-cell multiomics sequencing has emerged as a powerful tool to study disease-specific cell types and their relationship with genetic variants. However,...

Topics

Humans
Genome-Wide Association Study
Single-Cell Analysis
Polymorphism, Single Nucleotide
Databases, Genetic
Genetic Predisposition to Disease

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 39341994
DOI: 10.1038/s42003-024-06833-y
PMCID: PMC11439014

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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