Article

Single-Cell Sequencing Reveals Lineage-Specific Dynamic Genetic Regulation of Gene Expression During Human Cardiomyocyte Differentiation

2021-06-03

Abstract excerpt

Dynamic and temporally specific gene regulatory changes may underlie unexplained genetic associations with complex disease. During a dynamic process such as cellular differentiation, the overall cell type composition of a tissue (or an in vitro culture) and the gene regulatory profile of each cell can both experience significant changes over time. To identify these dynamic effects in high resolution, we collected...

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Literature Corpus work: 8ac5ed3f-37b4-55e5-aecd-5e7afe8b1047
DOI: 10.1101/2021.06.03.446970

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