Article

Single-cell allele-specific expression analysis reveals dynamic and cell-type-specific regulatory effects

2022-10-06

Abstract excerpt

Allele-specific expression, which measures the expression of two alleles of a gene in a diploid individual, is a powerful signal to study cis-regulatory effects. Comparing ASE across conditions, or differential ASE, can reveal context-specific gene regulation. Recently, single-cell RNA sequencing (scRNA-seq) has allowed the measurement of ASE at the resolution of individual cells, but there is a lack of statistica...

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Literature Corpus work: 885570da-0900-50a7-93c7-0a99a668642e
DOI: 10.1101/2022.10.06.511215

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