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Article

Single-cell allele-specific expression analysis reveals dynamic and cell-type-specific regulatory effects.

Nature communications - 9 Oct 2023

Qi Guanghao, Strober Benjamin J, Popp Joshua M, Keener Rebecca, Ji Hongkai, Battle Alexis

Abstract excerpt

Differential allele-specific expression (ASE) is a powerful tool to study context-specific cis-regulation of gene expression. Such effects can reflect the interaction between genetic or epigenetic factors and a measured context or condition. Single-cell RNA sequencing (scRNA-seq) allows the measurement of ASE at individual-cell resolution, but there is a lack of statistical methods to analyze such data. We...

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Identifiers

PMID: 37813843
DOI: 10.1038/s41467-023-42016-9
PMCID: PMC10562474

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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