Article

Human embryoid bodies as a novel system for genomic studies of functionally diverse cell types

2021-06-16

Abstract excerpt

Most disease-associated loci, though located in putatively regulatory regions, have not yet been confirmed to affect gene expression. One reason for this could be that we have not examined gene expression in the most relevant cell types or conditions. Indeed, even large-scale efforts to study gene expression broadly across tissues are limited by the necessity of obtaining human samples post-mortem, and almost excl...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: fbb527e4-68a2-564b-874a-f2b2ea1f0839
DOI: 10.1101/2021.06.16.448714

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Human embryoid bodies as a novel system for genomic studies of functionally diverse cell typesDOI 10.1101/2021.06.16.448714Read

Embryoid bodies facilitate comparative analysis of gene expression in humans and chimpanzees across dozens of cell typesSemantic proximity Read

Where Are the Disease-Associated eQTLs?Semantic proximity Read

Cell-type and dynamic state govern genetic regulation of gene expression in heterogeneous differentiating culturesSemantic proximity Read

Impacts of genomic networks governed by human-specific regulatory sequences and genetic loci harboring fixed human-specific neuro-regulatory single nucleotide mutations on phenotypic traits of Modern HumansSemantic proximity Read

eQTL studies: from bulk tissues to single cells.Semantic proximity Read

Single-Cell Analysis of Alternative Splicing and Gene Regulatory Network Reveals Remarkable Expression and Regulation Dynamics During Early Embryonic DevelopmentSemantic proximity Read

A limited set of transcriptional programs define major cell typesSemantic proximity Read

Gene expression in organoids: an expanding horizonSemantic proximity Read

Integrated transcriptomic analysis reveals a metabolically quiescent state and gene expression networks related to intermediate and mature human 8-cell stage embryo resembling cells <i>in vitro</i>Semantic proximity Read

Spatiotemporal transcriptome atlas of human embryos after gastrulation.Semantic proximity Read

Impacts of genomic networks governed by human-specific regulatory sequences and genetic loci harboring fixed human-specific neuro-regulatory single nucleotide mutations on phenotypic traits of modern humans.Semantic proximity Read

Genomic Architecture of Cells in Tissues (GeACT): Study of Human Mid-gestation FetusSemantic proximity Read