Article
The single-cell eQTLGen consortium.
eLife - 9 Mar 2020
van der Wijst Mgp, de Vries D H, Groot H E, Trynka G, Hon C C, Bonder M J, Stegle O, Nawijn M C, Idaghdour Y, van der Harst P, Ye C J, Powell J, Theis F J, Mahfouz A, Heinig M, Franke L
Abstract excerpt
In recent years, functional genomics approaches combining genetic information with bulk RNA-sequencing data have identified the downstream expression effects of disease-associated genetic risk factors through so-called expression quantitative trait locus (eQTL) analysis. Single-cell RNA-sequencing creates enormous opportunities for mapping eQTLs across different cell types and in dynamic processes, many of which...
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