Article

Gene neighbourhood integrity disrupted by CTCF loss <i>in vivo</i>

2017-09-12

Abstract excerpt

The mammalian genome is coiled, compacted and compartmentalized into complex non-random three-dimensional chromatin loops in the nucleus 1–3 . At the core of chromatin loop formation is CCCTC-binding factor (CTCF), also described as a “weaver of the genome” 45 . Anchored by CTCF, chromatin loops are proposed to form through a loop extrusion process 6 , organising themselves into gene neighbourhoods 2 that harb...

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Literature Corpus work: 70ecda6c-8069-577b-b16a-e9aa09a42f13
DOI: 10.1101/187393

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