Article

Structural perturbation of chromatin domains with multiple developmental regulators can severely impact gene regulation and development

2024-08-03

Abstract excerpt

Chromatin domain boundaries delimited by CTCF motifs can restrict the range of enhancer action. However, disruption of domain structure often results in mild gene dysregulation and thus predicting the impact of boundary rearrangements on animal development remains challenging. Here, we tested whether structural perturbation of a chromatin domain with multiple developmental regulators can result in more acute gene...

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Literature Corpus work: 10892e3b-f0ef-5c15-9a6f-e98f6fdb2414
DOI: 10.1101/2024.08.03.606480

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