Article

<i>Ctcf</i> Haploinsufficiency Mediates Intron Retention in A Tissue-specific Manner

2019-11-22

Abstract excerpt

CTCF is a master regulator of gene transcription and chromatin organization with occupancy at thousands of DNA target sites. CTCF is essential for embryonic development and somatic cell viability and has been characterized as a haploinsufficient tumor suppressor. Increasing evidence demonstrates CTCF as a key player in several alternative splicing (AS) regulatory mechanisms, including transcription elongation, reg...

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Literature Corpus work: 40432fdc-4b99-54c7-8b53-86bacfc93db5
DOI: 10.1101/851923

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