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Article

Ctcf haploinsufficiency mediates intron retention in a tissue-specific manner.

RNA biology - 1 Jan 2021

Alharbi Adel B, Schmitz Ulf, Marshall Amy D, Vanichkina Darya, Nagarajah Rajini, Vellozzi Melissa, Wong Justin Jl, Bailey Charles G, Rasko John Ej

Abstract excerpt

CTCF is a master regulator of gene transcription and chromatin organisation with occupancy at thousands of DNA target sites genome-wide. While CTCF is essential for cell survival, CTCF haploinsufficiency is associated with tumour development and hypermethylation. Increasing evidence demonstrates CTCF as a key player in several mechanisms regulating alternative splicing (AS), however, the genome-wide impact of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32816606
DOI: 10.1080/15476286.2020.1796052
PMCID: PMC7834090

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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