Article

Perturbational fitness analysis of CRISPR screens uncovers information-theoretic relation between gene function and selection

2025-05-01

Abstract excerpt

Despite major advances in genetic screening technology, a formal approach for quantifying gene function remains underdeveloped, thereby limiting the utility of these techniques in deciphering the complex behavior of human cells. In this study, we leverage information theory with a perturbational analysis of replicator dynamics to characterize functional drivers of selection in pooled CRISPR screens. Our approach c...

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Literature Corpus work: 5eaf65b4-12ed-5b5a-9c23-116241fd67f7
DOI: 10.1101/2025.04.29.651199

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