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Article

Toward an integrated map of genetic interactions in cancer cells.

Molecular systems biology - 21 Feb 2018

Rauscher Benedikt, Heigwer Florian, Henkel Luisa, Hielscher Thomas, Voloshanenko Oksana, Boutros Michael

Abstract excerpt

Cancer genomes often harbor hundreds of molecular aberrations. Such genetic variants can be drivers or passengers of tumorigenesis and create vulnerabilities for potential therapeutic exploitation. To identify genotype-dependent vulnerabilities, forward genetic screens in different genetic backgrounds have been conducted. We devised MINGLE, a computational framework to integrate CRISPR/Cas9 screens originating...

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Identifiers

PMID: 29467179
DOI: 10.15252/msb.20177656
PMCID: PMC5820685

Genes

GANAB
PRKCSH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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