Article

Somatic mutations distinguish melanocyte subpopulations in human skin

2025-02-08

Abstract excerpt

To better understand the homeostatic mechanisms governing melanocytes, we performed deep phenotyping of clonal expansions of single melanocytes from human skin. In total, we interrogated the mutational landscapes, gene expression profiles, and morphological features of 297 melanocytes from 31 donors. To our surprise, a population of melanocytes with low mutation burden was maintained in sun damaged skin. These mel...

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Literature Corpus work: c43ff834-3c9f-562f-a17b-5b322840fc80
DOI: 10.1101/2025.02.07.637114

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