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A longitudinal single-cell and spatial multiomic atlas of pediatric high-grade glioma

23 Apr 2026

Abstract excerpt

Pediatric high-grade glioma (pHGG) is an incurable central nervous system malignancy that is a leading cause of pediatric cancer death. While pHGG shares many similarities with adult glioma, it comprises distinct disease entities. In this study, we longitudinally profile a molecularly diverse cohort of 16 pHGG patients through single-nucleus RNA and ATAC sequencing, whole-genome sequencing, and CODEX spatial...

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PMID: 38496580
DOI: 10.1016/j.xcrm.2026.102766

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