Multi-pronged analysis of pediatric low-grade glioma reveals a unique tumor microenvironment associated with BRAF alterations

Abstract excerpt

Pediatric low-grade gliomas (pLGG) comprise 35% of all brain tumors. Despite favorable survival, patients experience significant morbidity from disease and treatments. A deeper understanding of pLGG biology is essential to identify novel, more effective, and less toxic therapies. We utilized single cell RNA sequencing (scRNA-seq), spatial transcriptomics, and cytokine analyses to characterize and understand tumor...

Topics

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• Brain Neoplasms
• Child
• Exome Sequencing
• Gene Expression Profiling
• Glioma
• Glioma Diagnosis and Treatment
• Phenotype
• Single-cell and spatial transcriptomics

Identifiers and source

Literature Corpus work

7f9a4e2f-bf69-5268-acd1-cc194ac84984

DOI

10.1101/2024.04.05.588294