Back to search

Article

Mapping Tumor Microenvironment and Treatment Response of Diffuse Midline Glioma Using Multiplexed Immunofluorescence and AI Models

2025-03-25

Abstract excerpt

<h4>Background</h4> Despite its clinical promise in non-solid tumor, immunotherapy is yet to show significant clinical efficacy for brain tumors including pediatric diffuse midline glioma (DMG). This indicated the need to fully explore DMG immune tumor microenvironment (TME). <h4>Method</h4> Whole brains (49 DMGs, 20 non-DMG, 10 non-malignant) from 79 pediatric patients were used to establish a tissue microarray...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
23fd25c3-3147-5654-a344-d86a12c196ff
DOI
10.1101/2025.03.23.644698
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Mapping Tumor Microenvironment and Treatment Response of Diffuse Midline Glioma Using Multiplexed Immunofluorescence and AI ModelsDOI 10.1101/2025.03.23.644698
Single-cell spatial analysis of pediatric high-grade glioma reveals a novel population of SPP1 <sup>+</sup> /GPNMB <sup>+</sup> myeloid cells with immunosuppressive and tumor-promoting capabilitiesSemantic proximity
<i>De novo</i> H3.3K27M-altered Diffuse Midline Glioma in human brainstem organoids to dissect GD2 CAR T cell functionSemantic proximity
A longitudinal single-cell and spatial multiomic atlas of pediatric high-grade gliomaSemantic proximity
Multiomics blueprint of PANoptosis in deciphering immune characteristics and prognosis stratification of glioma patientsSemantic proximity
Cancer-myeloid cell invasive program in pediatric-type diffuse high-grade gliomaSemantic proximity
New insights into the Immune TME of adult-type diffuse gliomas.Semantic proximity
A living pediatric brain tumor atlas reveals histomolecular diversity and therapeutic vulnerabilities for precision neuro-oncologySemantic proximity
Immune landscape of isocitrate dehydrogenase stratified human gliomasSemantic proximity
A longitudinal single-cell and spatial multiomic atlas of pediatric high-grade gliomaSemantic proximity
Microglia and monocyte-derived macrophages drive progression of pediatric high-grade gliomas and are transcriptionally shaped by histone mutations.Semantic proximity
Multi-omic landscape of human gliomas from diagnosis to treatment and recurrenceSemantic proximity
A road map for the treatment of pediatric diffuse midline glioma.Semantic proximity
Select a neighboring publication to make it the new centre.