Article

Estradiol reverses excitatory synapse loss in a cellular model of neuropsychiatric disorders

2018-10-28

Abstract excerpt

Loss of glutamatergic synapses is thought to be a key cellular pathology associated with neuropsychiatric disorders including schizophrenia (SCZ) and major depressive disorder (MDD). Genetic and cellular studies of SCZ and MDD using in vivo and in vitro systems have supported a key role for dysfunction of excitatory synapses in the pathophysiology of these disorders. Recent clinical studies have demonstrated tha...

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Literature Corpus work: 7019269a-5372-567a-af05-62353630b229
DOI: 10.1101/455113

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