Article
Disrupted-In-Schizophrenia 1 regulates integration of newly generated neurons in the adult brain.
Cell - 21 Sept 2007
Duan Xin, Chang Jay H, Ge Shaoyu, Faulkner Regina L, Kim Ju Young, Kitabatake Yasuji, Liu Xiao-bo, Yang Chih-Hao, Jordan J Dedrick, Ma Dengke K, Liu Cindy Y, Ganesan Sundar, Cheng Hwai-Jong, Ming Guo-li, Lu Bai, Song Hongjun
Abstract excerpt
Adult neurogenesis occurs throughout life in discrete regions of the adult mammalian brain. Little is known about the mechanism governing the sequential developmental process that leads to integration of new neurons from adult neural stem cells into the existing circuitry. Here, we investigated roles of Disrupted-In-Schizophrenia 1 (DISC1), a schizophrenia susceptibility gene, in adult hippocampal neurogenesis....
Topics
- Action Potentials
- Animals
- Carrier Proteins
- Cell Differentiation
- Cell Lineage
- Cell Movement
- Cell Proliferation
- Cell Size
- Dendrites
- Dentate Gyrus