Article
A Disc1 mutation differentially affects neurites and spines in hippocampal and cortical neurons.
Molecular and cellular neurosciences - 1 May 2013
Lepagnol-Bestel A M, Kvajo M, Karayiorgou M, Simonneau M, Gogos J A
Abstract excerpt
A balanced chromosomal translocation segregating with schizophrenia and affective disorders in a large Scottish family disrupting DISC1 implicated this gene as a susceptibility gene for major mental illness. Here we study neurons derived from a genetically engineered mouse strain with a truncating lesion disrupting the endogenous Disc1 ortholog. We provide a detailed account of the consequences of this mutation...
Topics
Join the communities discussing this publication.