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Article

Disc1 point mutations in mice affect development of the cerebral cortex.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 2 Mar 2011

Lee Frankie H F, Fadel Marc P, Preston-Maher Kate, Cordes Sabine P, Clapcote Steven J, Price David J, Roder John C, Wong Albert H C

Abstract excerpt

Disrupted-in-Schizophrenia 1 (DISC1) is a strong candidate gene for schizophrenia and other mental disorders. DISC1 regulates neurodevelopmental processes including neurogenesis, neuronal migration, neurite outgrowth, and neurotransmitter signaling. Abnormal neuronal morphology and cortical architecture are seen in human postmortem brain from patients with schizophrenia. However, the etiology and development of...

Topics

Amino Acid Substitution
Animals
Cerebral Cortex
Female
Growth Inhibitors
Mice
Mice, Inbred C57BL
Mice, Knockout
Mice, Transgenic
Nerve Tissue Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neurogenesis

Neurons

Point Mutation

Polymorphism, Single Nucleotide

Pregnancy

Source

Open in PubMed Open full text

Identifiers

PMID: 21368031
DOI: 10.1523/JNEUROSCI.4219-10.2011
PMCID: PMC6623921

Genes

DISC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Disc1 point mutations in mice affect development of the cerebral cortex.PMID 21368031Read ↗

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A mutation in mouse Disc1 that models a schizophrenia risk allele leads to specific alterations in neuronal architecture and cognition.Semantic proximity Read ↗

DISC1 in Schizophrenia: Genetic Mouse Models and Human Genomic ImagingSemantic proximity Read ↗

Behavioral alterations associated with targeted disruption of exons 2 and 3 of the Disc1 gene in the mouse.Semantic proximity Read ↗

Schizophrenia-related neural and behavioral phenotypes in transgenic mice expressing truncated Disc1.Semantic proximity Read ↗

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Specific developmental disruption of disrupted-in-schizophrenia-1 function results in schizophrenia-related phenotypes in mice.Semantic proximity Read ↗

A schizophrenia-associated mutation of DISC1 perturbs cerebral cortex development.Semantic proximity Read ↗

A Disc1 mutation differentially affects neurites and spines in hippocampal and cortical neurons.Semantic proximity Read ↗

Inducible expression of mutant human DISC1 in mice is associated with brain and behavioral abnormalities reminiscent of schizophrenia.Semantic proximity Read ↗

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Disrupted‐in‐Schizophrenia‐1 (DISC1)Semantic proximity Read ↗

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