Article
Deletion of densin-180 results in abnormal behaviors associated with mental illness and reduces mGluR5 and DISC1 in the postsynaptic density fraction.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 9 Nov 2011
Carlisle Holly J, Luong Tinh N, Medina-Marino Andrew, Schenker Leslie, Khorosheva Eugenia, Indersmitten Tim, Gunapala Keith M, Steele Andrew D, O'Dell Thomas J, Patterson Paul H, Kennedy Mary B
Abstract excerpt
Densin is an abundant scaffold protein in the postsynaptic density (PSD) that forms a high-affinity complex with αCaMKII and α-actinin. To assess the function of densin, we created a mouse line with a null mutation in the gene encoding it (LRRC7). Homozygous knock-out mice display a wide variety of abnormal behaviors that are often considered endophenotypes of schizophrenia and autism spectrum disorders. At the...
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