Article
Interaction between FEZ1 and DISC1 in regulation of neuronal development and risk for schizophrenia.
Neuron - 17 Nov 2011
Kang Eunchai, Burdick Katherine E, Kim Ju Young, Duan Xin, Guo Junjie U, Sailor Kurt A, Jung Dhong-Eun, Ganesan Sundar, Choi Sungkyung, Pradhan Dennis, Lu Bai, Avramopoulos Dimitrios, Christian Kimberly, Malhotra Anil K, Song Hongjun, Ming Guo-li
Abstract excerpt
Disrupted-in Schizophrenia 1 (DISC1), a susceptibility gene for major mental disorders, encodes a scaffold protein that has a multifaceted impact on neuronal development. How DISC1 regulates different aspects of neuronal development is not well understood. Here, we show that Fasciculation and Elongation Protein Zeta-1 (FEZ1) interacts with DISC1 to synergistically regulate dendritic growth of newborn neurons in...
Topics
- Adaptor Proteins, Signal Transducing
- Adult
- Aged
- Animals
- Case-Control Studies
- Cells, Cultured
- Female
- Gene Knockdown Techniques
- Genetic Association Studies
- Hippocampus