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Article

Interaction between FEZ1 and DISC1 in regulation of neuronal development and risk for schizophrenia.

Neuron - 17 Nov 2011

Kang Eunchai, Burdick Katherine E, Kim Ju Young, Duan Xin, Guo Junjie U, Sailor Kurt A, Jung Dhong-Eun, Ganesan Sundar, Choi Sungkyung, Pradhan Dennis, Lu Bai, Avramopoulos Dimitrios, Christian Kimberly, Malhotra Anil K, Song Hongjun, Ming Guo-li

Abstract excerpt

Disrupted-in Schizophrenia 1 (DISC1), a susceptibility gene for major mental disorders, encodes a scaffold protein that has a multifaceted impact on neuronal development. How DISC1 regulates different aspects of neuronal development is not well understood. Here, we show that Fasciculation and Elongation Protein Zeta-1 (FEZ1) interacts with DISC1 to synergistically regulate dendritic growth of newborn neurons in...

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Source

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Identifiers

PMID: 22099459
DOI: 10.1016/j.neuron.2011.09.032
PMCID: PMC3222865

Genes

DISC1
FEZ1
NDEL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Interaction between FEZ1 and DISC1 in regulation of neuronal development and risk for schizophrenia.PMID 22099459Read ↗

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Schizophrenia in translation: disrupted in schizophrenia (DISC1): integrating clinical and basic findings.Semantic proximity Read ↗

DISC1 puts the brakes on neurogenesis.Semantic proximity Read ↗

Understanding the role of DISC1 in psychiatric disease and during normal development.Semantic proximity Read ↗

Linking neurodevelopmental and synaptic theories of mental illness through DISC1.Semantic proximity Read ↗

Molecular mechanism of schizophrenia with reference to disrupted-in-schizophrenia 1 (DISC1).Semantic proximity Read ↗

DISC1: a key lead in studying cortical development and associated brain disorders.Semantic proximity Read ↗

Proteomic Studies Reveal Disrupted in Schizophrenia 1 as a Key Regulator Unifying Neurodevelopment and Synaptic FunctionSemantic proximity Read ↗

DISC1-NDEL1/NUDEL protein interaction, an essential component for neurite outgrowth, is modulated by genetic variations of DISC1.Semantic proximity Read ↗

Specific developmental disruption of disrupted-in-schizophrenia-1 function results in schizophrenia-related phenotypes in mice.Semantic proximity Read ↗

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