Article

GABAergic neuron dysregulation in a human neurodevelopmental model for major psychiatric disorders

2024-09-23

Abstract excerpt

“GABA dysfunction” is a major hypothesis for the biological basis of schizophrenia with indirect supporting evidence from human post-mortem brain and genetic studies. Patient-derived induced pluripotent stem cells (iPSCs) have emerged as a valuable platform for modeling psychiatric disorders, and previous modeling has revealed glutamatergic synapse deficits. Whether GABAergic synapse properties are affected in pat...

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Literature Corpus work: 4fcceba1-f12b-59bc-88e5-0ab20f9a8bd4
DOI: 10.1101/2024.09.23.614564

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