Article
Synaptic dysregulation in a human iPS cell model of mental disorders.
Nature - 20 Nov 2014
Wen Zhexing, Nguyen Ha Nam, Guo Ziyuan, Lalli Matthew A, Wang Xinyuan, Su Yijing, Kim Nam-Shik, Yoon Ki-Jun, Shin Jaehoon, Zhang Ce, Makri Georgia, Nauen David, Yu Huimei, Guzman Elmer, Chiang Cheng-Hsuan, Yoritomo Nadine, Kaibuchi Kozo, Zou Jizhong, Christian Kimberly M, Cheng Linzhao, Ross Christopher A, Margolis Russell L, Chen Gong, Kosik Kenneth S, Song Hongjun, Ming Guo-li
Abstract excerpt
Dysregulated neurodevelopment with altered structural and functional connectivity is believed to underlie many neuropsychiatric disorders, and 'a disease of synapses' is the major hypothesis for the biological basis of schizophrenia. Although this hypothesis has gained indirect support from human post-mortem brain analyses and genetic studies, little is known about the pathophysiology of synapses in patient...
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